Christian way. Christ'mas, n. Lord's Birthday, Dec. Cbristorogy, n. Cymri ; Welsh. Cimine'rian, adj. Bic'ely, n. Cine'ma, n. Cingalese', adj. Cinque' Ports, n. Circas'sian, adj. Circe'tn, adj. Ciroen'fdan, adj. Roman to the circus. Oister'dan, adj. His province is South of the Trent. Clementine d. Clo'ven, p. Olomp, v. Clntoh, v. CO'-aid, n. Ooast'lng, pr. COC'cyz, n. CO'balt, n. Cockaigne', n. CO'don, n. COg'niiance, n. COg'niauit, adj. COg'-wheel, n. CObib'it, strain. Also Colosseum. CoUi'sioo, n.
Colnm'bian, adj. OOlnm'biC, adj. COl'nmn, n. CompU'ance, n. Complaten'sian, adj. Comte and the posi' tive philosophy. OOn'cept, n. Holy the See and a secular power. OOQCln'siTe, adj. OOn'flox, n. Confu'cian, adj. Congregationalism Coogrega' tb:m! Congrega'tionalist, n. ConiTeiae, n. Co'noid, like;. Contin'nal, adj. COOk'y, n. COOp'er, n. CO-op'erant, adj. Copernican the system. Cop' tic, ad.
American snake. COr'nice, n , a projection from the top of a wall or range of. Oord'ing, n. OOr'morant, n. COTOllate, adj. COTO'ns, n. COTrel'atively, adv. C0rv6e', n. Coryban'tic, adj. COSh'er, v. CO'sily, adv. Cor'sican, adj. Cor'tes, ft. CO'terie, n. COUpi', n. COT'ering, pr. COOS'in, n. OOT'in, n. CO'ving, pr. COW'-pox, n. OOw'aTd, n. COW'boy, n. A corruption of the French crevice.
Croatian, adj. Cris'pin, n. Christian emof Salvation; great trial; a cross-breed. CTOss'-armed, n. Cromwellisn, rel. Holy Land. Crusta'cea, n. CTOwn'prinoe, n. CTOZ, n. Ca'ban, adj. Col'dee, n. COl'taral, adj. CU'pel, n. Cyp'rian, adj. Cyrena'io, adj. Oym'ric, adj. Car, n. Da'cian, adj.
Daed'alus, n. Dane'geld, n. Daae'gelt, Daaegeld. Dann'bian, adj. Data'ria, n. December, n. When the year's reckoning began in March, the. Mobirise is perfect for non-techies who are not familiar with the intricacies of web design and prefer to work as visually as possible. Also great for pro-coders for fast prototyping and small customers' projects. Start with creating a new website and picking up the theme.
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Build sites that sparkle in a mobile world! Article Google Scholar. Jones, B. Multi-university research teams: shifting impact, geography, and stratification in science. Xie, Y. Principles of scientific research team formation and evolution. Natl Acad. USA , — Falk-Krzesinski, H.
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Uzzi, B. Atypical combinations and scientific impact. Kuhn, T. All AML samples used see Supplementary Table 3 were from patients who were treated at City of Hope and normal bone marrow or mobilized peripheral blood stem cells were obtained from healthy HL donors.
Samples were acquired with signed informed consent and the procedure was approved by the City of Hope Institutional Review Board, in accordance with an assurance filed with and approved by the Department of Health and Human Services.
Calvin J. Ai14 Cre tdTomato reporter mice Stock No. Preleukemic analysis was performed 6 weeks after the last dose of poly I:C injection. Mice were monitored for leukemia development and survival for up to 1 year. AML transplant was performed via tail vein i. In vivo administration of miRisten or scramble SCR control was performed by daily retro-orbital i.
All experimental procedures were performed in accordance with federal and state government guidelines and established institutional guidelines and protocols approved by the Institutional Animal Care and Use Committee at City of Hope. BM mononuclear cells were collected from femurs, tibias, and pelvis using a mortar and pestle 33 , 36 , For fluorescence activated cell-sorting FACS analyses, cells were stained with fluorescently labeled antibodies in phosphate-buffered saline PBS with 0.
Antibodies used included are listed in Supplementary Table 4. Acquired data were analyzed by Flowjo software TaqMan Assays and primer sequences are listed in Supplementary Tables 5 and 6.
The constructs were also conjugated with Cy3 to track the internalization in cells by flow cytometry. One nonbridging atom of oxygen on phosphate was replaced with sulfur. Human inv 16 AML cells were transplanted via i. Mice were treated with miRisten or SCR control by retro-orbital i. This dose and schedule were selected based on empirical testing showing effective knockdown, efficacy, tolerability, and feasibility of drug synthesis.
Virus were produced and transduced as previously described Primary antibodies used are listed in Supplementary Table 8. The information for antibodies used is presented in Supplementary Table 8.
The lysate was centrifuged, and supernatant was collected. Individual libraries were prepared using a unique index primer in order to allow for pooling of multiple samples prior to sequencing.
The library was quantified using qPCR. Sequencing of 50 cycles was performed on a HiSeq Illumina Inc. The expression level of mouse mature miRNAs from Sanger mirBase v18 were counted as previously described Raw RNA-seq sequences were subjected to adapter trimming using Trimmomatic v0. The trimmed reads were aligned to mouse genome mm10 using Tophat v2.
The log-rank test was used to assess significant differences between survival curves. All statistical analyses were performed using Prism version 8. Sample sizes chosen are indicated in the individual figure legends and were not based on formal power calculations to detect prespecified effect sizes. A p value less than 0. All experiments are repeated independently with similar results at least two times. Further information on research design is available in the Nature Research Reporting Summary linked to this article.
The raw data and processed RNA-seq data associated with Fig. Raw miRNA-seq data associated with Fig. Source data are provided with this paper. Bloomfield, C. Acute myeloid leukemia.
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Core-binding factors in hematopoiesis and immune function. Oncogene 23 , — Speck, N. Core-binding factors in haematopoiesis and leukaemia. Cancer 2 , — Science , — Prebet, T. Acute myeloid leukemia with translocation 8;21 or inversion 16 in elderly patients treated with conventional chemotherapy: a collaborative study of the French CBF-AML intergroup.
Ustun, C. Core-binding factor acute myeloid leukemia with inv 16 : older age and high white blood cell count are risk factors for treatment failure. Ambros, V. The functions of animal microRNAs. Nature , — Bartel, D. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell , — Bohnsack, M. RNA 10 , —
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